Impacts of SARS-CoV-2 Variants of Concern on Diagnostics
From the below table of Summary of phenotypic impacts of variants of concern, we acknowledge that Alpha variant has limited impact - S gene target failure and no impact on overall result from multiple target RT-PCR and no impact on Ag RDTs observed. Beta variant has no impact on RT-PCR or Ag RDTs observed. None reported to date about Gamma and Delta variants impacts on diagnostics.
Summary of phenotypic impacts of variants of concern —— abstracted from COVID-19 Weekly Epidemiological Update Edition 54, published 24 August 2021 by World Health Organization (WHO)
|Transmissibility||Increased transmissibility and secondary attack rate||Increased transmissibility||Increased transmissibility||Increased transmissibility and secondary attack rate.Similar transmissibility between vaccinated and unvaccinated individuals|
|Disease severity||Increased risk of hospitalization, possible increased risk of severity and mortality||Not confirmed, possible increased risk of in-hospital mortality||Not confirmed, possible increased risk of hospitalization||Increased risk of hospitalization|
|Risk of reinfection||Neutralizing activity retained, risk of reinfection remains similar||Reduction in neutralizing activity reported; T cell response elicited by D614G virus remains effective||Moderate reduction in neutralizing activity reported||Reduction in neutralizing activity reported|
|Impacts on diagnostics||Limited impact – S gene target failure (SGTF); no impact on overall result from multiple target RTPCR, No impact on Ag RDTs observed||No impact on RTPCR or Ag RDTs observed||None reported to date||None reported to date|
*Generalized findings as compared to previously/co-circulating variants. Based on emerging evidence, including non-peer-reviewed preprint articles and reports, all subject to ongoing investigation and revision.